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Essentials Blend (NMN + TMG)
The Essentials Blend - A compounded mixture of nicotinamide mononucleotide (NMN) & Trimethylglycine (TMG).
NMN is a hero longevity ingredient, best known for its ability to increase energy levels and reverse the physical effects of aging. Clinical studies have linked NMN to improved physical performance, better sleep quality, increased cognitive function, and even reversing grey hair.
Taking NMN can deplete the methyl groups in your body, and so you need to take it alongside TMG (a source of methyl groups) to ensure the NMN can keep working its magic. This is why Zest has compounded NMN and TMG to create the ultimate longevity Essentials Blend.
When taken orally NMN will:
- Increase NAD+ biosynthesis
- Suppress age-related tissue inflammation
- Enhancing insulin secretion and insulin action
- Improve mitochondrial function
- Improve neuronal function in the brain
What's included:
Caps per bottle: 30
MG per cap: 500mg NMN & 500mg TMG
Item form: Acid Resistant Capsule
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Why is the Zest Membership better?
Membership
Zest is your one stop shop and the only fully comprehensive longevity program incorporating supplements, testing and lifestyle tracking for the best price.
Pay 23 cents more per month for 2x the amount of NMN compared to Novos.
What are the benefits of each supplement?
Learn about the benefits of each ingredient below, turn on ‘Geek Mode’ to get technical.
Vitamin D3 / K2 / mg
Berberine
- Nature’s ozempic
- Lowers blood glucose levels/improves insulin sensitivity
- Reduced appetite and increased fullness from meals
- Slows aging
Berberine is a plant-derived compound that has been extracted from bark and used in Chinese and Ayurvedic medicine for centuries. When taken as a supplement it has profound benefits on glucose metabolism, lowering glucose levels and improving insulin sensitivity. Recent research has also shown that it can reduce the risk of cardiovascular disease and lower inflammation. As it is not found in any foods, it can only be taken as a supplement.
Vitamin D3 / K2 / mg
Pterostilbene
- 4x better cellular uptake than resveratrol (what our competitors sell)
- Powerful antioxidant and anti-inflammatory properties
- Extends healthspan in animals
- Activates sirtuins, promoting DNA repair
Pterostilbene is found naturally in plants such as blueberries and grapes. It is closely related to resveratrol, a compound that has received a lot of attention as a longevity compound. While resveratrol has failed to show efficacy in recent human trials, pterostilbene is taken up into cells four times more effectively and therefore shows much more promise. It has powerful antioxidant and anti-inflammatory properties and extends healthspan in animals.
Vitamin D3 / K2 / mg
Glycine
- Reduce the risk of chronic disease
- Improves sleep
Glycine and N-acetylcysteine (NAC) are both amino acids, the building blocks your body uses to produce proteins. Glycine reduces the risk of chronic disease and improves sleep, while NAC enhances exercise performance and mood. NAC and glycine are both needed to produce glutathione, a powerful antioxidant. Taking both compounds together improves mitochondrial function, muscle strength and inflammation.
Why combine NMN & TMG
NMN has been proven to provide anti-aging benefits by enhancing the function of common proteins (Sirtuins and PARPS), through NAD+ production.
NMN is clinically proven to improve:
- Energy production in mitochondria
- Oxidative stress
- DNA damage
- Cognitive impairement
- Inflammatory conditions
TMG has been approved by the FDA to lower homocysteine in our blood plasma which can help fight off cardiovascular issues.
NMN & TMG work together as NMN-induced NAD+ production requires the use of the methylation process, supported by TMG. TMG is known as a methyl group donor. NMN and TMG together offer one of the best ways to activate and support the healthy function of our internal anti-aging processes.
What is NMN?
NMN (Nicotinamide mononucleotide) stands as the hero of longevity supplements. Derived from niacin (Vitamin B3), NMN helps to boost NAD+ in your cells. This can lead to a boost in your cellular energy levels, improved cognitive health for a sharper mind, improved cardiovascular health through better vascular function, and an improved metabolism.
Zest’s Pure NMN Capsules use Enteric Coated Acid-Resistant non-GMO capsules that are designed to resist stomach acids and absorb in the small intestine, improving the bioavailability of the NMN by 30% compared to regular capsules.
What are the effects?
NMN and in turn NAD+ affect energy levels, sleep quality, mental focus, fatigue levels and metabolism, to slow your rate of aging.
What is TMG?
TMG, or Trimethylglycine, is a compound derived from beets and other plants. Also known as betaine, TMG plays a role in supporting methylation processes in the body. It is often included in supplements for its potential benefits in promoting liver health, cardiovascular function, and overall cellular methylation.
Trimethylglycine operates in the body as a methyl donor for various crucial biological processes. By donating methyl groups, TMG supplements aids the conversion of homocysteine to methionine, contributing to a balanced methylation cycle. It also ensures supplements the use up methyl groups (such as NMN) can work effectively.
What are the effects?
TMG improves the efficiency of NMN supplements, and acts to improve mood, detoxification in the liver, reduce joint inflammation and promote muscle development.
What are the benefits of each supplement?
Learn about the benefits of each ingredient below, turn on ‘Geek Mode’ to get technical.
NMN
- Increases energy levels
- Improves athletic performance
- Improves sleep
- Protects against metabolic disorders.
- Preserves cognitive function as you age
TMG
- Enhances muscle-building
- Reduce the risk of cardiovascular disease by lowering levels of homocysteine
- Healthy liver function and detoxification
- Prevents chronic disease
Why are Zest Supplements better?
7.2 g of actives included every day, more than any other longevity company on the market.
Membership
What to look for in an age test?
Why did we build Functional Age?
Many tests take a single proxy for biological age (Inflammation age, DNA methylation etc.) However, these tests were not designed to give insight into an individuals personal longevity, but for research purposes, predominantly in animal models.
Imagine a scenario where an individual in their 60’s receives an age score in their 20’s. The data is not actionable nor does it provide insight on how to improve your healthy lifespan.
Epigenetic clocks can’t actually tell you much about your own health. That’s because they were designed to assess large groups of people, not individuals. Consequently, their results can be unreliable. (NY Times 2024.)
To tackle this problem Zest has created the only multifaceted age testing system, from the ground up, Functional Age. We benchmark the biomarkers linked to aging and pull data from your blood, wearable device, and functional performance tests. Then provide analysis that is actionable and relevant to the individual taking the test, not the mouse or yeast trial that other common tests were developed for.
If you have excellent blood biomarkers, but warning signs present in your cognitive performance, Zest will detect it, rather than telling you that you are fit to live to 120. Giving you the necessary information to optimize this area and create a truly personalized action plan for your aging journey.
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Did you know..
Blood Tests can predict your age with incredible accuracy?
Our blood test is comprised of the 10 markers which have been shown repeatedly to be the most closely linked to healthspan and lifespan.
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Which supplement is right for me?
Your Pro-Longevity Routine.
Delivered to your door.
Zest Science's science-backed approach harnesses your body's natural mechanisms to promote a longer, healthier life.
We’ve curated clinical grade ingredients and the most holistic biological age test on the market using methodologies backed by decades of research and real clinical experience.
Frequently Asked Questions
- Order your functional age test via our website
- Receive your at-home finger prick blood test kit, collect your dried blood sample and send it off in the prepaid mailer.
- Download our app and receive your blood test results directly to your phone, no need for any follow-up results appointments
- Repeat steps 6 & 7 until you find the perfect and most optimized longevity protocol for you, and then use the app to stay accountable.
- Download our app and select a membership that works for you.
- Start following our science-backed longevity protocol.
- Watch your functional age score come down, continue adding the new recommendations to your daily protocol, and iterate towards a lower biological age over time.
- Your chosen longevity supplement stack, delivered monthly.
- Zest longevity blood panel delivered every 3 months. This is an at-home finger-prick blood test consisting of the 9 blood biomarkers most closely linked to healthspan and lifespan.
- Access to the Zest app.
- Zest biological age calculation (coming soon).
The supplement subscription only includes supplements and app access, no blood tests. Without the blood biomarkers, we are unable to calculate biological age.
Mainstream supplements are typically designed to augment ingredients which you could regularly find in your diet to help you meet your daily recommendations. Longevity molecules are different because:
1) you don’t find any of these ingredients in your regular diet and
2) there are no established daily recommendations of these ingredients.
These ingredients have come out of recent cutting-edge research on how to biologically slow the aging process. There aren’t any government guidelines recommending certain levels of these ingredients to promote health, since they are so new and they target the aging process as a whole rather than focusing on a specific disease. Our ingredients cannot be found in most supermarkets or drug stores.
- At 7.2 g grams per dose, we have the highest amount of pure active ingredients of any other longevity company on the market, so you’re actually getting therapeutic doses that make a difference.
- We have the purest and highest quality ingredients, and provide purity reports and 3rd party Lab Testing as well as sourcing information for all ingredients.
- We don’t mess around with vitamin gummies, green juice blends, or other influencer fads which aren’t backed by science. We only supply the real deal, high quality and therapeutic doses backed by 100+ clinical trials.
- We separate our supplement packs into hydrophobic and hydrophilic to optimize absorption and reduce gastrointestinal upset. This means the ingredients are actually getting into your cells, unlike for many multivitamin companies which just cause you to make expensive pee.
- We have expertly curated our supplement stacks to target all 12 root causes of aging, making you biologically younger on the inside.
Zest’s functional age calculation is the most accurate and holistic biological age score on the market, and the only one which takes into account your cognitive function as well as your physical health. We use a combination of blood biomarkers, digital biomarkers and functional biomarkers (including memory tests) which we run through our machine learning algorithm to give you the most accurate and research-backed biological age measurement yet. Our blood test includes markers for your cholesterol levels, hormone levels, liver enzymes, and other tests grounded in 100+ years of research (the OG science, not just the latest fads). We then add this to our digital biomarkers such as resting heart rate, sleep, mood, VO2 max score, and other metrics which give real insight into your day to day functionality. Finally we include grip strength and some cognitive tests as part of our “functional biomarkers” and together this makes up the data that goes into our functional age algorithm to give you a result for your biological age.
At Zest, we want to make longevity easy. We have a team of medical doctors and longevity scientists constantly examining the latest literature to determine which ingredients should go into the ultimate life-extending supplement stack. We continuously update these packs as new research emerges to ensure the ingredients you’re taking are at the forefront of medical and scientific research. No need to spend hours doing your own research, we are the experts and we have you covered! Just subscribe to the membership and Zest takes care of the rest.
The Zest app is downloadable from all countries. Currently our blood tests and supplement packs are currently only available in the USA and Canada.
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Join our community
More than 10,000+ people have Joined Zest and unlocked their personalized pro-longevity plans. Get started with Zest today!